In between these layers, the parathyroid glands are found. These include: T3 is so named because it contains three atoms of iodine per molecule and T4 contains four atoms of iodine per molecule. The isthmus lies over the 2 nd and 3 rd rings of the trachea Thyroid isthmusectomy is a surgical procedure that excises only the thyroid isthmus. PDF | The thyroid gland is an endocrine gland with high vascularise. In healthy euthyroid animals, 0.1% of total serum T 4 is free (not bound to thyroid hormone–binding proteins), whereas ~1% of circulating T …

The thyroid isthmus lies about halfway between the thyroid cartilage (the Adam's apple) and the sternal notch.

The thyroid uses iodine to produce vital hormones. The thyroid gland, which is made up of the right and left lobes connected to the isthmus (or “bridge), produces and releases thyroid hormones. The thyroid gland is located below the Adam's apple wrapped around the trachea (windpipe).
It also acts as a covering for the second and the third tracheal rings.

Thyroid hormones control functions such as body temperature, digestion and heart functions.


When the thyroid is its normal size, you can’t feel it. The thyroid gland, a highly vascular endocrine gland, is composed of two lateral lobes connected by a narrow median isthmus thus giving an 'H' shaped appearance to the gland. A wide range of morphological variations and developmental anomalies of the thyroid gland have been reported in the literature.

It allows excision of a lesion without the exposure of the tracheoesophageal grooves.

The thyroid (Glandula thyreoidea) is a butterfly-shaped organ located in the cervical region in front of the trachea. The thyroid hormones are created from iodine and tyrosine. The thyroid hormones have a wide range of effects on the human body. Length of thyroid isthmus ( ) and 2- to 24-hour iodine uptake ratios ( ) were significantly associated with treatment failure, which was defined as a persistent hyperthyroid status after RAI therapy. Different types of thyroid disorders affect either its structure or function. The major function of the thyroid hormone–binding proteins is probably to provide a hormone reservoir in the plasma and to “buffer” hormone delivery into tissue. The agenesis of isthmus of thyroid gland as noted may be due to a high separation of thyroglossal duct which can engender two independent thyroid lobes and pyramidal lobe with the absence of isthmus. Thyroid isthmus Function. It has two lateral lobes connected in the centre by the isthmus.. The thyroid has two side lobes, connected by a bridge (isthmus) in the middle. It has an important body function control function and acts as a hormone storage. It joins one of the lower thirds of the lateral lobes with the other. Case report: a congenital anomaly of thyroid gland with agenesis of isthmus and presence of … We aimed to demonstrate that isthmusectomy could be a safe alternative to thyroid lobectomy with isthmusectomy in patients with nodules confined to the isthmus or the pyramidal lobe. A disturbed thyroid function affects a wide variety of body and organ functions.

A thin area of tissue in the gland's middle, known as the isthmus, joins the two thyroid lobes on each side. The lobes are enclosed with two connective tissue capsules. Rare anomalies are agenesis or hemi-agenesis of thyroid gland, agenesis of isthmus alone or aberrant thyroid glands [1,2] In all the higher primates and human, the gland is composed of two lateral lobes joined by an isthmus located in the anterior cervical region, at the level of the second to fourth tracheal rings and protected by the infrahyoid muscles.

There are usually four parathyroid glands, found on the posterior surface of the thyroid gland.

Age, sex, body mass index, pre-RAI thyroid function, or thyroid-stimulating immunoglobulin levels were not associated with treatment outcome. The primary function of the thyroid is the production of the iodine-containing thyroid hormones, triiodothyronine (T3) and thyroxine (T4) and the peptide hormone calcitonin.

Usually agenesis of isthmus is difficult to determine unless the patients present for other thyroid pathologies.

The thyroid gland sits anteriorly in the neck, just inferior to the thyroid cartilage.It is located deep to the overlying strap muscles (sternohyoid, sternothyroid and omohyoid). The structure indicated is the isthmus of the thyroid gland..

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